منابع مشابه
Checkmate to CHK1 in T-cell ALL?
DNA replication ensures accurate duplication of the original genetic information present in a cell in order for it to be properly transmitted to daughter cells. However, replication can be perturbed, for instance in rapidly dividing cancer cells, in a process referred to as replication stress (RS). Checkpoint kinase 1 (CHK1) is an essential component of the ATR-dependent DNA damage-response pat...
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Two IgM monoclonal antibodies (MAb) with strong reactivity for granulocytes and to a lesser extent for lurkat cell lines were established by immunizing BALBI c mice with a histiocytic cell line (UY37). These two MAbs (designated as 6C9 and 4C4) reacted with blast cells of T-acute lymphoblastic leukemia (T-ALL) and acute myelogenous leukemia (AML) patients as well as leukemic cells from pat...
متن کاملCheckMATE
In der produzierenden Industrie – insbesondere in der Pharma-, Automobilund Zulieferindustrie – steigen die Qualitätsanforderungen in Richtung Null-Fehler-Produktion. Als Antwort kommen zunehmend automatische Verfahren zur Fehlerbehebung und Fehlervermeidung in der Produktionskette zum Einsatz. Integrierte Qualitätsund Prozessdaten von Sensorsystemen und Anlagensteuerungen stellen hierfür die B...
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Background T cell immunotherapy is one promising approach to improve outcomes for patients with AML; however, infused T cells do not redirect resident T cells to tumors. To overcome this, we have genetically modified T cells to produce a secretable, bispecific T cell engager (ENG-T cells). Consistent synthesis of engagers by T cells should be superior to the direct infusion of the recombinant b...
متن کاملdetermination of a shared epitope on cells from acute myelogenic leukemia (aml) and t-acute lymphoblastic leukemia ( t-all)
two igm monoclonal antibodies (mab) with strong reactivity for granulocytes and to a lesser extent for lurkat cell lines were established by immunizing balbi c mice with a histiocytic cell line (uy37). these two mabs (designated as 6c9 and 4c4) reacted with blast cells of t-acute lymphoblastic leukemia (t-all) and acute myelogenous leukemia (aml) patients as well as leukemic cells from patients...
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ژورنال
عنوان ژورنال: Blood
سال: 2021
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2021011497